2024-08-09T14:25:35 n105801

Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study

Viewed: 178

Case Presentation

A 40-year-old female presented with 7 years of intractable cough and shortness of breath. There was no significant exposure history. She was a non-smoker and suffered from grass and dust mite allergy. On examination, she had finger clubbing and end-inspiratory fine crackles at both lung bases. A chest CT showed evidence of ground glass opacities, interlobular septal thickening, and focal areas of air trapping in both lung bases, in line with interstitial lung disease suggestive of hypersensitivity pneumonitis. A complex lung function test showed restrictive lung disease with a forced vital capacity of 1.65 L (45% of predicted value) and a total lung capacity of 2.7 L (56% of predicted value). A left-sided video-assisted thoracotomy lung biopsy in late 2017 showed extensive scarring and honeycombing with peribronchial fibrosis and granulomata, which confirmed her diagnosis of hypersensitivity pneumonitis. Her symptoms worsened in early 2018, and she developed a type 1 respiratory failure requiring oxygen. She underwent pulse therapy with an intravenous injection of 1 g of cyclophosphamide and methylprednisolone, and treatment continued with a weaning dose of oral prednisolone. Unfortunately, there was no response to this treatment course, and she underwent bilateral sequential lung transplantation in December 2018.

Geographical area of data collection

kmlPolyCoords
153.555242,-9.141203 137.995957,-9.141203 137.995957,-29.177898 153.555242,-29.177898 153.555242,-9.141203

Publications

de Silva, Tharushi, Apte, Simon H., Voisey, Joanne, Spann, Kirsten, Tan, Maxine E., Divithotawela, Chandima, Chambers, Daniel, & O'Sullivan, Brendan (2023) Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study. International Journal of Molecular Sciences, 24(19), Article number: 14442. https://eprints.qut.edu.au/243854/

Research areas

Regulatory T cells
Chronic hypersensitivity pneumonitis
CD39
Single-cell transcriptomics

Cite this collection

de Silva, Tharushi; Apte, Simon; Voisey, Joanne; Spann, Kirsten; Tan, Maxine; Divithotawela, Chandima; Chambers, Daniel; O'Sullivan, Brendan; (2023): Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study. Queensland University of Technology. (Text) http://researchdatafinder.qut.edu.au/individual/n105801

Data file types

Adobe (.pdf)

Licence


Creative Commons Attribution-NonCommercial-Share Alike 4.0 (CC-BY-NC-SA)
http://creativecommons.org/licenses/by-nc-sa/4.0/

Copyright

© Queensland University of Technology, 2022.

Dates of data collection

From 2017-05-01 to 2020-05-31

Connections

Has chief investigator
Tharushi De Silva  (Researcher)

Contacts

Other

Date record created:
2024-05-23T09:47:09
Date record modified:
2024-08-09T14:25:35
Record status:
Published - Open Access