2022-03-09T15:36:45 n144171

Development and in-vitro evaluation of controlled release drug-loaded polymeric nanoparticles from dry powder inhaler formulation

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We investigated the development of ciprofloxacin (CIP) loaded poly(2-ethyl-2-oxazoline) (PEtOx) nanoparticles (NPs) for potential pulmonary delivery from dry powder inhaler (DPI) formulations against LRTIs. NPs were prepared using a straightforward co-assembly reaction carried out by the intermolecular hydrogen bonding among PEtOx, tannic acid (TA), and CIP. The prepared NPs were characterised by scanning electron microscopy (SEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction analysis (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). The CIP was determined by validated HPLC and UV spectrophotometry methods.

The CIP loading into the PEtOx was between 21–67% and increased loading was observed with the increasing concentration of CIP. The NP sizes of PEtOx with or without drug loading were between 196–350 nm and increased with increasing drug loading. The in vitro CIP release showed the maximum cumulative release of about 78% in 168 h with a burst release of 50% in the first 12 h. The kinetics of CIP release from NPs followed non-Fickian or anomalous transport thus suggesting the drug release was regulated by both diffusion and polymer degradation. The in vitro aerosolisation study carried out using a Twin Stage Impinger (TSI) at 60 L/min air flow showed the fine particle fraction (FPF) between 34.4% and 40.8%. The FPF was increased with increased drug loading. The outcome of this study revealed the potential of the polymer PEtOx as a carrier for developing CIP-loaded PEtOx NPs as DPI formulation for pulmonary delivery against LRTIs.

Geographical area of data collection

kmlPolyCoords
153.026123,-27.467712

Publications

Sabuj, Mohammad Zaidur Rahman, Dargaville, Tim, Nissen, Lisa, & Islam, Nazrul (2021) Inhaled ciprofloxacin-loaded poly(2-ethyl-2-oxazoline) nanoparticles from dry powder inhaler formulation for the potential treatment of lower respiratory tract infections. PLoS ONE, 16(12), Article number: e0261720. https://eprints.qut.edu.au/227275/

Research areas

Polymers
Lung delivery
Ciprofloxacin
Nanoparticles
Nanomedicine
Lower respiratory tract infections

Cite this collection

Sabuj, Mohammad Zaidur Rahman; Islam, Nazrul; (2021): Development and in-vitro evaluation of controlled release drug-loaded polymeric nanoparticles from dry powder inhaler formulation. Queensland University of Technology. (Dataset) http://researchdatafinder.qut.edu.au/individual/n144171

Data file types

Adobe .pdf

Licence


Creative Commons Attribution 4.0 (CC-BY)
http://creativecommons.org/licenses/by/4.0/

Copyright

© Mohammad Zaidur Rahman Sabuj, 2022.

Dates of data collection

From 2019-06-09 to 2021-08-12

Connections

Has association with
Lisa Nissen  (Researcher)
Nazrul Islam  (Researcher)
Tim Dargaville  (Researcher)

Contacts

Name: Mr Mohammad Zaidur Rahman Sabuj

Other

Date record created:
2022-02-02T16:39:08
Date record modified:
2022-03-09T15:36:45
Record status:
Published - Open Access