2024-08-29T15:34:28 n19813

Studies on the equine enteroinsular axis

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Equine insulin dysregulation is a burgeoning and poorly understood problem associated with high morbidity. Based on the premise that insulin dysregulation originates in the foregut, this innovative project aimed to identify the earliest pathogenic factors of disease by investigating two key hormones: ghrelin and GLP-2; and, whether a specific genetic mutation underlies insulin dysregulation.

Using innovative approaches, the project examined gastrointestinal factors influencing insulin dysregulation, which will enable the identification of at-risk animals and pinpoint novel treatment strategies. Improved disease treatment and prevention will reduce the suffering associated with painful and often lethal co-morbidities.

The gastrointestinal peptides glucagon-like peptide-1 and glucagon-like peptide-2 are key components of the enteroinsular axis and have a role in metabolic diseases. They are coded by the proglucagon gene (GCG) and released from L cells in the gastrointestinal tract. Very little investigation of these peptides has been undertaken in horses, despite horses being prone to metabolic dysfunction. This dataset contains basic physiological data from in vitro studies of the physiology of these two peptides in healthy horse tissues. 

Initial dataset contains 2 spreadsheets: Studies on equine glucagon-like peptide 1 and Studies on equine glucagon-like peptide 2.  Additional spreadsheet (GLP1 inhibitor study_raw data) uploaded 1/11/23. 

Geographical area of data collection

kmlPolyCoords
153.090912,-27.497471

Publications

P.E.M. Sibthorpe, D.M. Fitzgerald, M.N. Sillence, M.A. de Laat. (2024) Studies in vitro of equine intestinal glucagon-like peptide-2 secretion, Journal of Equine Veterinary Science, Volume 142 http://dx.doi.org/10.1016/j.jevs.2024.105179
Sibthorpe, Poppy E. (2022) Studies on glucagon-like peptide-2 (GLP-2) and the equine gastrointestinal tract. PhD thesis, Queensland University of Technology. https://eprints.qut.edu.au/232700/
Fitzgerald, DM, Cash, CM, Dudley, KJ, Sibthorpe, PEM, Sillence, MN, de Laat, MA. 2023. Expression of the GCG gene and secretion of active glucagon-like peptide-1 varies along the length of intestinal tract in horses. Equine Vet J. https://doi.org/10.1111/evj.14020
de Laat, M.A., Fitzgerald, D.M., Harris, P.A., Bailey, S.R. (2023). A glucagon-like peptide-1 receptor antagonist reduces the insulin response to a glycemic meal in ponies, Journal of Animal Science, Vol. 101. http://dx.doi.org/https://doi.org/10.1093/jas/skad389
Sibthorpe, PEM, Fitzgerald, DM, Sillence, MN, de Laat, MA. 2023. Associations between feeding and glucagon-like peptide-2 in healthy ponies. Equine Vet J. https://doi.org/10.1111/evj.14004
de Laat MA, Fitzgerald DM. 2023. Equine metabolic syndrome: Role of the enteroinsular axis in the insulin response to oral carbohydrate. Vet J. https://doi.org/10.1016/j.tvjl.2023.105967

Research areas

Equine
Hyperinsulinaemia
Animal physiology
Veterinary anatomy and physiology
Animal obesity
Enteroinsular axis
Insulin

Cite this collection

de Laat, Melody; Sillence, Martin; Fitzgerald, Danielle; Sibthorpe, Poppy; (2023): Studies on the equine enteroinsular axis. Queensland University of Technology. (Dataset) https://doi.org/10.25912/RDF_1682306093217

Data file types

3 x Excel spreadsheets (.xlsx)

Licence


Creative Commons Attribution-NonCommercial-No Derivatives 4.0 (CC-BY-NC-ND)
http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright

© Queensland University of Technology, 2023.

Dates of data collection

From 2018-03-21 to 2022-07-30

Connections

Has association with
Martin Sillence  (Researcher)
Has chief investigator
Melody de Laat  (Researcher)

Contacts

Other

Date record created:
2023-04-21T11:44:49
Date record modified:
2024-08-29T15:34:28
Record status:
Published - Open Access