2022-05-04T14:49:08 n24555

Dissolvable 3D printed moulds to augment architecture of melt electrowritten tubular scaffolds

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Melt electrowriting (MEW) is an additive manufacturing technique capable of fabricating microfibre thermoplastic scaffolds which is growing in popularity for tissue engineering applications. MEW is able to produce micron-scale biocompatible constructs through electrodynamic jet deposition with a high-level of control over fibre deposition. By depositing MEW fibres on a rotating cylindrical collector (mandrel), tubular constructs can be fabricated to mimic cylindrical anatomical tissues such as blood vessels.

This proof-of-concept study leveraged the water solubility of PVA moulds to support tubular MEW scaffold fabrication in complex and patient-specific geometries. The dissolution rate of 3D printed PVA moulds was measured in water under constant stirring for 2 hours. MEW scaffolds were printed on then removed from either PVA or non-dissolvable PLA moulds, and the preservation of the MEW scaffold morphology was assessed. The non-dissolvable PLA moulds significantly damaged the MEW scaffolds while the PVA dissolvable moulds enabled the preservation the of scaffold geometry and could be separated from the mould with ease. This study demonstrated the capability for MEW to be leveraged as a technique for producing anatomically relevant tubular structures.

The associated data is the Supplementary Materials for the following journal article:

Brooks-Richards, Trent, Paxton, Naomi, Allenby, Mark, & Woodruff, Mia (2022) Dissolvable 3D printed PVA moulds for melt electrowriting tubular scaffolds with patient-specific geometry. Materials and Design, 215, Article number: 110466. https://eprints.qut.edu.au/228424/.

Access rights

This data is part of an ongoing study.

Geographical area of data collection

kmlPolyCoords
153.015265,-27.452709

Publications

Brooks-Richards, Trent, Paxton, Naomi, Allenby, Mark, & Woodruff, Mia (2022) Dissolvable 3D printed PVA moulds for melt electrowriting tubular scaffolds with patient-specific geometry. Materials and Design, 215, Article number: 110466. https://eprints.qut.edu.au/228424/

Research areas

Biofabrication
Biomedical engineering
Engineering design
Biochemistry and cell biology

Cite this collection

Brooks-Richards, Trent; Paxton, Naomi; Allenby, Mark; Woodruff, Mia; (2022): Dissolvable 3D printed moulds to augment architecture of melt electrowritten tubular scaffolds . Queensland University of Technology. (Model) https://doi.org/10.25912/RDF_1650941419744

Data file types

3D model (STL file) to produce a 3D printed mandrel mould to augment the underlying architecture of tubular melt electrowritten scaffolds.

Licence


Creative Commons Attribution 4.0 (CC-BY)
http://creativecommons.org/licenses/by/4.0/

Copyright

© Queensland University of Technology, 2022.

Dates of data collection

From 2021-07-17 to 2021-08-30

Connections

Has association with
Mark Allenby  (Researcher)
Naomi Paxton  (Researcher)
Has chief investigator
Mia Woodruff  (Researcher)

Contacts

Name: Professor Mia Woodruff
Phone: +61 7 3138 7778

Other

Date record created:
2022-04-04T17:29:24
Date record modified:
2022-05-04T14:49:08
Record status:
Published - Open Access