2021-11-11T10:02:03 n29264

Diversity of epithelial-mesenchymal phenotypes in circulating tumour cells from prostate cancer patient-derived xenograft models

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Metastasis is the leading cause of cancer-related deaths worldwide. Epithelial-mesenchymal plasticity (EMP) status of primary tumours has relevance to metastatic potential and therapy resistance. Circulating tumour cells (CTCs) provide a window into the metastatic process, and molecular characterisation of CTCs in comparison to their primary tumours could lead to a better understanding of the mechanisms involved in the metastatic cascade.

In this study, paired blood and tumour samples were collected from 4 prostate cancer patient-derived xenograft (PDX) models (BM18, LuCaP70, LuCaP96, LuCaP105) and assessed using an EMP-focused, 42 gene human-specific, nested quantitative RT-PCR assay. CTC burden varied amongst the various xenograft models with LuCaP96 having the highest number of CTCs per mouse (mean: 704; median: 31) followed by BM18 (mean: 101; median: 21), LuCaP70 (mean: 73; median: 16) and LuCaP105 (mean: 57; median: 6).

Location of data collection

kmlPolyCoords
153.028076,-27.467712

Publications

Hassan, Sara, Blick, Tony, Thompson, Rik, & Williams, Elizabeth (2021) Dysregulated epithelial-mesenchymal plasticity in circulating tumour cells from prostate cancer patient-derived xenograft models. Cancers. https://eprints.qut.edu.au/209628/

Research areas

Hybrid cells
Circulating tumour cell clusters
Prostate specific antigen
Patient derived xenograft models
Epithelial mesenchymal plasticity
Metastasis
Prostate cancer

Cite this collection

Hassan, Sara; Blick, Tony; Thompson, Erik ; Williams, Elizabeth (2021): Diversity of epithelial-mesenchymal phenotypes in circulating tumour cells from prostate cancer patient-derived xenograft models. Queensland University of Technology. (Dataset) http://researchdatafinder.qut.edu.au/individual/n29264

Partner institution

Translational Research Institute (TRI) https://www.tri.edu.au/

Data file types

Data files are in .pptx format.

Licence


Creative Commons Attribution 4.0 (CC-BY)
http://creativecommons.org/licenses/by/4.0/

Copyright

© Queensland University of Technology, 2021.

Connections

Has association with
Elizabeth Williams  (Researcher)
Rik Thompson  (Researcher)

Contacts

Name: Sara Hassan

Other

Date record created:
2021-04-30T22:32:44
Date record modified:
2021-11-11T10:02:03
Record status:
Published - Open Access