Table of model parameters: Towards a quantitative theory of epidermal calcium profile formation in unwounded skin
This data consists of a table containing model parameters obtained from experimental literature, with subsequent calculations performed as necessary (as described in Supporting Information, Text S1, in the associated publication). All data used in this work is either provided in Table 1 or extracted from figures published in references 26 and 28 (Mauro et al. 1998; Behne et al. 2003) using the program xyExtract.
The research conducted forms part of a PhD thesis, "Mathematical Models of Calcium and Tight Junctions in Normal and Reconstructed Epidermis." Proposed and mathematically examined was a theory of calcium profile formation in unwounded mammalian epidermis based on: changes in keratinocyte proliferation, fluid and calcium exchange with the extracellular fluid during these cells' passage through the epidermal sub-layers, and the barrier functions of both the stratum corneum and tight junctions localised in the stratum granulosum. Using this theory, a mathematical model was developed that predicts epidermal sub-layer transit times, partitioning of the epidermal calcium gradient between intracellular and extracellular domains, and the permeability of the tight junction barrier to calcium ions.
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