Data from a study into the association between Prostinogen/KLK15 (Kallikrein 15 ) SNPs (single nucleotide polymorphisms) and prostate cancer risk in Queensland and PLCO (Prostate, Lung, Colon and Ovarian) study groups
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Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease.
A comprehensive analysis was performed of association of variants in the KLK15 gene with prostate cancer risk and aggressiveness by genotyping tagSNPs, as well as putative functional SNPs identified by extensive bioinformatics analysis.
Twelve out of 22 SNPs, selected on the basis of linkage disequilibrium pattern, were analyzed in an Australian sample of 1,011 histologically verified prostate cancer cases and 1,405 ethnically matched controls. Replication was sought from two existing genome wide association studies (GWAS): the Cancer Genetic Markers of Susceptibility (CGEMS) project and a UK GWAS study.
Geographical area of data collection
kmlPolyCoords
153.552920,-9.929730 137.994575,-9.929730 137.994575,-29.178588 153.552920,-29.178588 153.552920,-9.929730
Publications
Batra J, Lose F, O'Mara T, Marquart L, Stephens C, et al. (2011) Association between Prostinogen (KLK15) Genetic Variants and Prostate Cancer Risk and Aggressiveness in Australia and a Meta-Analysis of GWAS Data. PLoS ONE 6(11): e26527.
https://doi.org/10.1371/journal.pone.0026527
Research areas
Chemistry
Cancer
Genetics
Biotechnology
Cite this collection
Batra, Jyotsna; Lose, Felicity; O'Mara, Tracy; Marquart, Louise; Stephens, Carson; Alexander, Kimberly; Srinivasan, Srilakshmi; Eeles, Rosalind A.; Easton, Douglas F.; Olama, Ali Amin Al; Kote-Jarai, Zsofia; Guy, Michelle; Muir, Kenneth; Lophatananon, Artitaya; Rahman, Aneela A.; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Chambers, Suzanne; Gardiner, Robert A.; Aitken, Joanne; Yaxley, John; Kedda, Mary-Anne; Clements, Judith A.; Spurdle, Amanda B. (2011): Association between KLK15 SNPs and prostate cancer risk in the QLD and PLCO study groups. Table_2.xls. PLOS ONE.
Batra, Jyotsna (2015): Data from a study into the association between Prostinogen/KLK15 (Kallikrein 15 ) SNPs (single nucleotide polymorphisms) and prostate cancer risk in Queensland and PLCO (Prostate, Lung, Colon and Ovarian) study groups. Queensland University of Technology. (Dataset) https://doi.org/10.4225/09/5858c8714e829
Related information
Queensland Institute of Medical Research Berghofer
http://www.qimrberghofer.edu.au/
Access the data
Data file types
.xls
Licence
Copyright
© Queensland University of Technology, 2015.
Dates of data collection
From 2010 to 2011
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Date record created:
2015-04-21T10:54:26
Date record modified:
2019-08-22T10:39:05
Record status:
Published - Open Access