2015-06-11T21:29:04 n7047

Longitudinal assessment of neuropathy in type 1 diabetes using novel ophthalmic markers (LANDMark)

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The LANDMark study is an investigator-masked, prospective, longitudinal, controlled, natural history (observational) study conducted at two sites – Brisbane, Australia and Manchester, UK. The LANDMark study aims to: observe the natural history of diabetic neuropathy using novel non-invasive ophthalmic tests; prospectively characterise changes in corneal and retinal structural and functional (corneal subbasal nerve plexus, corneal sensation threshold, retinal thickness and retinal sensitivity) parameters in individuals with and without diabetic neuropathy; determine the predictive validity of the tests to measure these; and identify demographic and metabolic risk factors associated with these changes over time.


Development and validation of the QUT corneal nerve grading scale http://eprints.qut.edu.au/67490/
Corneal sensitivity as an ophthalmic marker of diabetic neuropathy http://eprints.qut.edu.au/39846/
Optimal image sample size for corneal nerve morphometry http://eprints.qut.edu.au/54153/
Repeatability of measuring corneal subbasal nerve fiber length in individuals with Type 2 Diabetes http://eprints.qut.edu.au/39395/
Standardising corneal nerve fibre length for nerve tortuosity increases its association with measures of diabetic neuropathy http://eprints.qut.edu.au/67489/
Retinal nerve fibre layer thickness is associated with higher risk of foot ulceration in diabetic peripheral neuropathy http://eprints.qut.edu.au/67980/
Wide-field assessment of the human corneal subbasal nerve plexus in diabetic neuropathy using a novel mapping technique http://eprints.qut.edu.au/54150/
Corneal markers of diabetic neuropathy http://eprints.qut.edu.au/46514/
The Glenn A. Fry Award Lecture 2010: Ophthalmic markers of diabetic neuropathy http://eprints.qut.edu.au/52611/
Morphometric stability of the corneal subbasal nerve plexus in healthy individuals a 3-year longitudinal study using corneal confocal microscopy http://eprints.qut.edu.au/75638/
LANDMark Study. Longitudinal assessment of novel ophthalmic diabetic markers http://eprints.qut.edu.au/67755/
Non-contact laser-scanning confocal microscopy of the human cornea in vivo http://eprints.qut.edu.au/66397/
Exploring retinal and functional markers of diabetic neuropathy http://eprints.qut.edu.au/38384/
Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy http://eprints.qut.edu.au/54177/
Assessment of diabetic neuropathy using novel corneal markers http://eprints.qut.edu.au/67982/
Longitudinal assessment of neuropathy in type 1 diabetes using novel ophthalmic markers (LANDMark) : study design and baseline characteristics http://eprints.qut.edu.au/67487/
Corneal sensitivity is related to established measures of diabetic peripheral neuropathy http://eprints.qut.edu.au/54179/
Visual sensitivity loss in the central thirty degrees of visual field is associated with diabetic peripheral neuropathy http://eprints.qut.edu.au/54176/

Research areas

retinal nerve fibre layer
corneal confocal microscopy
diabetic neuropathy
Medical and health sciences
natural history
ocular coherance tomography
flicker perimetry
Ophthalmology and optometry
non-contact corneal aesthesiometry
corneal subbasal nerve plexus
corneal nerve mapping

Partner institution

Princess Alexandra Hospital http://www.health.qld.gov.au/pahospital/
The University of Queensland http://www.uq.edu.au/
The University of Manchester http://www.manchester.ac.uk/

Dates of data collection

From 2009-08-01 to 2014-08-31


Has association with
Nathan Efron  (Researcher)
Has participant
Katie Edwards  (Researcher)
Has chief investigator
Nathan Efron  (Researcher)



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Published - Open Access