2016-12-19T11:55:09 n7679

Animal monitoring data collected during multifaceted experiments from a sheep model being treated for smoke-induced acute lung injury using veno-venous extra corporeal membrane oxygenation

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The source of data for this study was from a sheep model being treated for smoke-induced acute lung injury using veno-venous extracorporeal membrane oxygenation, a form of extracorporeal life support (ECLS) developed to complement the treatment of acute lung injury in humans. During this type of ECLS, venous blood is carried from the patient to a gas exchange device where it becomes enriched with oxygen, has carbon dioxide removed, and is returned to the patient’s circulation in the right heart. This method can be used for treatment, as respiratory support during lung transplantation, and in critically ill patients with potentially reversible respiratory failure. The source study was an ongoing publicly funded animal experimentation study (Queensland University of Technology Animal Ethics Approval No. 110000053). The overall goal of the study was to provide useful information relevant to the sheep model, itself, and to those interested in large animal experimentation and veterinary medicine, generally. The specific objectives were: 1) use the raw data from the sheep model study to create a data management system for tabulating large data sets from human studies using animal models and, 2) analyse that data to provide biological information that is not currently available for sheep receiving ECLS following smoke-induced acute lung injury. Data from 19 adult mechanically ventilated ewes undergoing intensive care in a previous study evaluating a form of extracorporeal life support (treatment) for acute lung injury were used to develop a comprehensive method for processing manual and electronically gathered clinical observations. Eight sheep were injured by acute smoke inhalation prior to treatment (injured/treated), while another eight were not injured but treated (uninjured/treated). Two sheep were injured but not treated (injured/untreated), while one received room air instead of smoke as the injury, and was not treated (placebo/untreated). The data were then analysed for 11 physiological categories and compared between the two treated groups. Data consisted of separate files of real-time physiological data recorded on the hard drives of the monitoring devices (electronically acquired data), and parameters manually recorded by those monitoring the sheep under anaesthesia (manually acquired data), which included data from the electronic monitoring equipment, as back-up if the electronic monitor malfunctioned. Data were tabulated and processed using spreadsheet (Microsoft® Excel 2010, Microsoft Corporation). To meet the second objective, data from the groups, uninjured/treated and injured/treated groups were analysed. The means, medians and standard deviations of the weights of the sheep, where applicable, were tabulated. The physiological parameters of the groups were charted and compared against each other using one-way analysis of variance (ANOVA), where appropriate. Parameters between groups were compared using a paired two-tailed t-test. All p-values were two-sided and p < 0.05 was considered statistically significant. All statistical calculations were performed using GraphPad PRISM 6 software (GraphPad Software, La Jolla, CA, USA).

Geographical area of data collection

kmlPolyCoords
153.022343,-27.386832

Publications

Critical care management of sheep receiving extra-corporeal membrane oxygenation due to smoke induced acute lung injury (ECMO S-ALI) and acute sepsis. In: Australian and New Zealand College of Veterinary Scientists: College Science Week 2013, Surfers Paradise, Australia, (). 11-13 July 2013. https://espace.library.uq.edu.au/view/UQ:328112/CCM_ALI_of_Sheep.pdf
The impact of continuous flow from venovenous extracorporeal membrane oxygenation cannulae on tricuspid valve geometry and function. In: Heart Lung and Circulation: Abstracts for Cardiac Society of Australia and New Zealand Annual Scientific Meeting. 2013 ANZSCTS Annual Scientific Meeting, Darwin, NT Australia, (199-199). 22 - 25 August 2013. http://espace.library.uq.edu.au/view/UQ:328443
Contemporary data capture, anaesthesia monitoring and point-of-care technology in critical care research settings for animal models. In: Australian and New Zealand College of Veterinary Scientists: College Science Week 2013, Surfers Paradise, Australia, (). 11-13 July 2013. https://espace.library.uq.edu.au/view/UQ:328111/CDCAMP_Saul_Chemonges.pdf
A novel echocardiographic imaging technique, intracatheter echocardiography, to guide veno-venous extracorporeal membrane oxygenation cannulae placement in a validated ovine model. Intensive Care Medicine Experimental, 2 2: 1-13. http://dx.doi.org/doi:10.1186/2197-425X-2-2
Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care. BioMed Research International, 2014 468309: 1-17. http://dx.doi.org/doi:10.1155/2014/468309
Feasibility of a novel echocardiographic imaging technique, intracatheter echocardiography, to guide venovenous extracorporeal membrane oxygenation cannulae placement in a validated ovine model. In: Abstracts for the Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting. CSANZ 2013: 61st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand; in conjunction with the 37th Annual Scientific Meeting of the International Society for Heart Research, Gold Coast, QLD, Australia, (S180-S180). 8-11 August, 2013. http://dx.doi.org/doi:10.1016/j.hlc.2013.05.429
Feasibility of Perflutren Microsphere Contrast Transthoracic Echocardiography in the Visualization of Ventricular Endocardium during Venovenous Extracorporeal Membrane Oxygenation in a Validated Ovine Model. Echocardiography. http://dx.doi.org/10.1111/echo.12695

Research areas

Veterinary Medicine
animal models, sheep, veterinary medicine, veno-venous extracorporeal membrane oxygenation, lung

Cite this collection

Chemonges,Saul. (2015): Learning from critical care management of sheep receiving extra-corporeal membrane oxygenation for smoke-induced acute lung injury as a tool for processing large clinical datasets. [Queensland University of Technology]. http://dx.doi.org/10.4225/09/58573c7114c49

Licence


Creative Commons Attribution 4.0 (CC-BY)
http://creativecommons.org/licenses/by/4.0/

Copyright

© Queensland University of Technology

Dates of data collection

From 2012-09-01 to 2013-08-31

Connections

Has association with
Kimble Dunster  (Researcher)
Saul Chemonges  (Researcher)

Contacts

Name: Saul Chemonges

Other

Date record created:
2015-04-02T08:08:23
Date record modified:
2016-12-19T11:55:09
Record status:
Published - Open Access