Pharmacokinetic data for twelve therapeutic equine medications
Available in print format through the publication 'The pharmacokinetics of equine medications', this data collection consists of a series of tables containing basic drug information, as well as illustrations of the concentration of twelve important equine drugs in the blood and urine of horses at various time points after drug administration. For each therapeutic substance, the published tables and figures indicate the time taken for the drug to reach its maximum concentration in the blood, its rate of metabolism and removal from the bloodstream, and its metabolites to be eliminated from the body via the urine.
Data were collected by administering each medication to a group of twelve Standardbred and Thoroughbred horses housed at the Equine Centre, Charles Sturt University (Wagga Wagga, NSW). A second group of twelve Standardbred horses were housed at the Equine Centre, University of Queensland (Gatton, QLD).
All blood and urine samples were analysed by official Australian horseracing forensic laboratories. Standard analytical methods and instrumentation were used (usually LC-MS or GC-MS), following sample extraction procedures. All methods were fully validated involving the use of calibration standards and quality control samples. All experimental procedure were conducted in accordance with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes and were approved by the Animal Care and Ethics Committees of the University of Queensland and Charles Sturt University.
The pharmacokinetic data were analysed using WinSAAM software and STATA Statistical Software 11.1., with Modelling work undertaken at the University of Pennsylvania.
Data are relevant to veterinarians and veterinary researchers, horse owners and trainers, veterinary pharmaceutical companies, regulatory authorities in racing and other equine sports, and other sports drug testing agencies with the purposes of informing treatment protocols for sick or injured horses and assisting regulators in setting appropriate withholding times for equine medications in competition sports.
Access to the data should be negotiated with the primary contact, Martin Sillence.
All rights to the publication 'The pharmacokinetics of equine medications' are reserved by the Rural Industries Research and Development Corporation (RIRDC), excepting use as permitted under the Copyright Act 1968.