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Pharmacokinetic data for twelve therapeutic equine medications

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Available in print format through the publication 'The pharmacokinetics of equine medications', this data collection consists of a series of tables containing basic drug information, as well as illustrations of the concentration of twelve important equine drugs in the blood and urine of horses at various time points after drug administration. For each therapeutic substance, the published tables and figures indicate the time taken for the drug to reach its maximum concentration in the blood, its rate of metabolism and removal from the bloodstream, and its metabolites to be eliminated from the body via the urine.

Data were collected by administering each medication to a group of twelve Standardbred and Thoroughbred horses housed at the Equine Centre, Charles Sturt University (Wagga Wagga, NSW). A second group of twelve Standardbred horses were housed at the Equine Centre, University of Queensland (Gatton, QLD).

All blood and urine samples were analysed by official Australian horseracing forensic laboratories. Standard analytical methods and instrumentation were used (usually LC-MS or GC-MS), following sample extraction procedures. All methods were fully validated involving the use of calibration standards and quality control samples. All experimental procedure were conducted in accordance with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes and were approved by the Animal Care and Ethics Committees of the University of Queensland and Charles Sturt University.

The pharmacokinetic data were analysed using WinSAAM software and STATA Statistical Software 11.1., with Modelling work undertaken at the University of Pennsylvania.

Data are relevant to veterinarians and veterinary researchers, horse owners and trainers, veterinary pharmaceutical companies, regulatory authorities in racing and other equine sports, and other sports drug testing agencies with the purposes of informing treatment protocols for sick or injured horses and assisting regulators in setting appropriate withholding times for equine medications in competition sports.

Access to the data should be negotiated with the primary contact, Martin Sillence.

All rights to the publication 'The pharmacokinetics of equine medications' are reserved by the Rural Industries Research and Development Corporation (RIRDC), excepting use as permitted under the Copyright Act 1968.

Access rights

Queries concerning the data should be directed to Professor Martin Sillence at martin.sillence@qut.edu.au or by phoning +61 7 3138 2565. You could be required to indicate your intended use of the data and to fulfil other terms and conditions as determined by the data owners.

Geographical area of data collection

text
New South Wales, Australia; Queensland, Australia; Victoria, Australia; Pennsylvania, USA

Publications

G.K. Noble, A.R. McKinney, F.I. Schneiders, A.J. Dunstan, M.N. Sillence and R.C. Boston. (2010). Preliminary pharmacokinetics of acepromazine and its metabolite hydroxyethylepromazine sulfoxide. Australian Equine Science Symposium, 3-5 June 2010, Gold Coast, QLD, Australia, pp. 60. http://espace.library.uq.edu.au/eserv/UQ:237796/Equine_Science_Symposium_2010_proceedings.pdf
McGree, James, Noble, Glenys, Schneiders, Fiona, Dunstan, Anthony, McKinney, Andrew, Boston, Raymond, and Sillence, Martin. (2011). A Bayesian approach for estimating detection times in horses: exploring the pharmacokinetics of a urinary acepromazine metabolite. Journal of Veterinary Pharmacology and Therapeutics. (In Press) http://dx.doi.org/10.1111/j.1365-2885.2013.01389.x
M. Sillence, G. Noble, F. Schneiders, W. Bryden, J. Cawdell-Smith, M. De Laat, M. Jarrett, B. Young, A. McKinney, A. Cawley, J. Booth, J. Vine, L. Glowacki, J. McGree, R. Boston, S. Nelis, C. Kirkpatrick, N. Shaw and B. Smyth. (2012). The pharmacokinetics of equine medications. Rural Industries Research and Development Corporation (RIRDC), Barton ACT. Publication 11/117. https://rirdc.infoservices.com.au/downloads/11-117
S. Nelis, C. Sievers, M. Jarrett, L.M. Nissen, C.M.J. Kirkpatrick, P.N. Shaw. (2010). Quantitative analysis of lignocaine and metabolites in equine urine and plasma by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 878(22), pp. 2018-2022. https://doi.org/10.1016/j.jchromb.2010.05.042
G.K. Noble, J.H.Vine, M.N. Sillence and R.C. Boston. (2010). The metabolism of solu-cortef: subsequent distribution of hydrocortisone hemisuccinate and hydrocortisone. Australian Equine Science Symposium, 3-5 June 2010, Gold Coast, QLD, Australia, pp. 54. http://espace.library.uq.edu.au/eserv/UQ:237796/Equine_Science_Symposium_2010_proceedings.pdf

Research areas

Veterinary sciences
Animal production
Withholding times
Veterinary Pharmacology
Equine
Racing
Dope-testing
Veterinary pharmacology
Horses
Medications

Cite this collection

Sillence,Martin; McGree,James. (2012): Pharmacokinetic data for twelve therapeutic equine medications. [Queensland University of Technology]. https://doi.org/10.4225/09/587d6cdfbbc05

Related information

Troy Laboratories Australia http://www.troylab.com.au/
Racing and Wagering Western Australia http://www.rwwa.com.au/home/
Equestrian Australia http://www.equestrian.org.au/
Australian Harness Racing http://www.harness.org.au/
Charles Sturt University http://www.csu.edu.au/
Equine Veterinarians Australia http://eva.ava.com.au/
Australian Horse Industry Council http://www.horsecouncil.org.au/
Veterinary Manufacturers and Distributors Association http://www.vmda.com.au/
National Association of Testing Authorities, Australia http://www.nata.com.au/nata/
WinSAAM (simulation, analysis and modelling software), University of Pennsylvania http://www.winsaam.org/
University of Queensland http://www.uq.edu.au/

Copyright

© Rural Industries Research and Development Corporation (RIRDC).

Dates of data collection

From 2007 to 2012

Connections

Was collected by
James McGree  (Researcher)
Martin Sillence  (Researcher)

Contacts

Name: Martin Sillence
Phone: +61 7 3138 2565
Fax: +61 7 3138 1508

Other

Date record created:
2012-04-12
Date record modified:
2017-01-17T11:03:36
Record status:
Published - Open Access