Imaging prostate tissue lipids using isomer-resolved mass spectrometry

Name: Imaging prostate tissue lipids using isomer-resolved mass spectrometry
Creator: Mr Reuben Young
License: http://creativecommons.org/licenses/by-nc-sa/4.0/
Keywords: Isomer elucidation,MALDI-MSI,Lipidomics,Ozone-induced Dissociation,Cell Biology,Mass Spectrometry,Molecular Imaging,Prostate cancer,research data,data collections,research project

Young, Reuben; Claes, Britt; Bowman, Andrew; Williams, Elizabeth; Shepherd, Benjamin; Perren, Aurel; Poad, Berwyck; Ellis, Shane; Heeren, Ron; Sadowski, Martin; Blanksby, Stephen

doi:10.25912/RDF_1625715878910

Imaging prostate tissue lipids using isomer-resolved mass spectrometry

Viewed: 1255

Data sets associated with the main text figures and supplementary information for the Fronteirs in Endocrinology publication "Isomer-Resolved Imaging of Prostate Cancer Tissues Reveals Specific Lipid Unsaturation Profiles Associated With Lymphocytes and Abnormal Prostate Epithelia".

Data has been divided into primary folders, with labels referring to the relevant main/SI figure. Data folders will include raw data files generated by the analytical instruments (see METHODS section within the publication for more information), text files of specific data extracts, and image file types for microscopy and MALDI-MSI.

Geographical area of data collection

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1) QUT - Gardens Point Campus, P Block, Brisbane City, QLD 4000, Australia.

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3) Universiteitssingel - 50, 6229 ER Maastricht, Netherlands.

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2) TRI Princess Alexandra Hospital, Brisbane, QLD 4000, Australia.

Publications

Tousignant, Kaylyn D, Rockstroh, Anja, Poad, Berwyck L J, Talebi, Ali, Young, Reuben S E, Taherian Fard, Atefeh, Gupta, Rajesh, Zang, Tuo, Wang, Chenwei, Lehman, Melanie L, Swinnen, Johan V, Blanksby, Stephen J, Nelson, Colleen C, & Sadowski, Martin C (2020) Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer. Cancer & Metabolism, 8, Article number: 11. https://eprints.qut.edu.au/202211/

Paine, Martin, Poad, Berwyck, Eijkel, Gert, Marshall, David, Blanksby, Stephen, Heeren, Ron, & Ellis, Shane (2018) Mass spectrometry imaging with isomeric resolution enabled by ozone-induced dissociation. Angewandte Chemie (International Edition), 57(33), pp. 10524-10530. https://eprints.qut.edu.au/120319/

Young, Reuben S.E., Bowman, Andrew P., Williams, Elizabeth D., Tousignant, Kaylyn D., Bidgood, Charles L., Narreddula, Venkateswara R., Gupta, Rajesh, Marshall, David L., Poad, Berwyck L.J., Nelson, Colleen C., Ellis, Shane R., Heeren, Ron M.A., Sadowski, Martin C., & Blanksby, Stephen J. (2021) Apocryphal FADS2 activity promotes fatty acid diversification in cancer. Cell Reports, 34(6), Article number: 108738. https://eprints.qut.edu.au/208094/

Poad, Berwyck, Marshall, David, Harazim, Eva, Gupta, Raj, Narreddula, Venkateswara Reddy, Young, Reuben, Duchoslav, Eva, Campbell, J., Broadbent, James, Cvacka, Josef, Mitchell, Todd, & Blanksby, Stephen (2019) Combining charge-switch derivatization with ozone-induced dissociation for fatty acid analysis. Journal of the American Society for Mass Spectrometry, 30(10), pp. 2135-2143. https://eprints.qut.edu.au/131340/

Marshall, David, Criscuolo, Angela, Young, Reuben, Poad, Berwyck, Zeller, Martin, Reid, Gavin, Mitchell, Todd, & Blanksby, Stephen (2019) Mapping unsaturation in human plasma lipids by data-independent ozone-induced dissociation. Journal of the American Society for Mass Spectrometry, 30(9), pp. 1621-1630. https://eprints.qut.edu.au/130909/

Research areas

Isomer elucidation

MALDI-MSI

Lipidomics

Ozone-induced Dissociation

Cell Biology

Mass Spectrometry

Molecular Imaging

Prostate cancer

Cite this collection

Young, Reuben; Claes, Britt; Bowman, Andrew; Williams, Elizabeth; Shepherd, Benjamin; Perren, Aurel; Poad, Berwyck; Ellis, Shane; Heeren, Ron; Sadowski, Martin; Blanksby, Stephen; (2021): Imaging prostate tissue lipids using isomer-resolved mass spectrometry. Queensland University of Technology. (Collection) https://doi.org/10.25912/RDF_1625715878910

Partner institution

Translational Research Institute Australia https://www.tri.edu.au/translational-research-institute-australia

Maastricht MultiModal Molecular Imaging (M4I) https://www.maastrichtuniversity.nl/research/m4i-division-imaging-mass-spectrometry

Access the data

https://data.researchdatafinder.qut.edu.au/dataset/imaging-prostate-tissue

Data file types

Mass spec instrument files (.raw file folders) - to be used with Waters HDI or MassLynx software .txt files (tab delineated) with extracted data .fig files to be used with MatLab Image files (.png, .tif)