Lipid Isomer Compartmentalisation
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Datasets associated with the main text figures and supplementary information for the following publication:
Reuben S. E. Young, Andrew P. Bowman, Kaylyn D. Tousignant, Berwyck L. J. Poad, Jennifer H. Gunter, Lisa K. Philp, Colleen C. Nelson, Shane R. Ellis, Ron M. A. Heeren, Martin C. Sadowski, Stephen J. Blanksby. Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer. bioRxiv 2021.11.01.466716; doi: https://doi.org/10.1101/2021.11.01.466716
Data has been divided into primary folders, with labels referring to the relevant main/SI figure. Data folders will include raw data files generated by the analytical instruments (see METHODS section within the publication for more information), text files of specific data extracts, and image file types for microscopy and MALDI-MSI.
Access rights
Access to the data collection is covered by Creative Commons under the licence CC-BY-NC-SA. All use and distribution of this data must adhere to this licencing. Please contact Reuben Young for access to this dataset.
Geographical area of data collection
kmlPolyCoords
153.031676,-27.499037
kmlPolyCoords
5.716239,50.835141
kmlPolyCoords
153.030263,-27.477617
Publications
Paine, Martin, Poad, Berwyck, Eijkel, Gert, Marshall, David, Blanksby, Stephen, Heeren, Ron, & Ellis, Shane (2018) Mass spectrometry imaging with isomeric resolution enabled by ozone-induced dissociation. Angewandte Chemie (International Edition), 57(33), pp. 10524-10530.
https://eprints.qut.edu.au/120319/
Poad, Berwyck, Marshall, David, Harazim, Eva, Gupta, Raj, Narreddula, Venkateswara Reddy, Young, Reuben, Duchoslav, Eva, Campbell, J., Broadbent, James, Cvacka, Josef, Mitchell, Todd, & Blanksby, Stephen (2019) Combining charge-switch derivatization with ozone-induced dissociation for fatty acid analysis. Journal of the American Society for Mass Spectrometry, 30(10), pp. 2135-2143.
https://eprints.qut.edu.au/131340/
Marshall, David, Criscuolo, Angela, Young, Reuben, Poad, Berwyck, Zeller, Martin, Reid, Gavin, Mitchell, Todd, & Blanksby, Stephen (2019) Mapping unsaturation in human plasma lipids by data-independent ozone-induced dissociation. Journal of the American Society for Mass Spectrometry, 30(9), pp. 1621-1630.
https://eprints.qut.edu.au/130909/
Young, Reuben; Claes, Britt; Bowman, Andrew; Williams, Elizabeth; Shepherd, Benjamin; Perren, Aurel; Poad, Berwyck; Ellis, Shane; Heeren, Ron; Sadowski, Martin; Blanksby, Stephen; (2021): Imaging prostate tissue lipids using isomer-resolved mass spectrometry. Frontiers in Endocrinology. 12, pp. 859.
http://dx.doi.org/10.3389/fendo.2021.689600
Tousignant, Kaylyn D, Rockstroh, Anja, Poad, Berwyck L J, Talebi, Ali, Young, Reuben S E, Taherian Fard, Atefeh, Gupta, Rajesh, Zang, Tuo, Wang, Chenwei, Lehman, Melanie L, Swinnen, Johan V, Blanksby, Stephen J, Nelson, Colleen C, & Sadowski, Martin C (2020) Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer. Cancer & Metabolism, 8, Article number: 11.
https://eprints.qut.edu.au/202211/
Young, Reuben S.E., Bowman, Andrew P., Williams, Elizabeth D., Tousignant, Kaylyn D., Bidgood, Charles L., Narreddula, Venkateswara R., Gupta, Rajesh, Marshall, David L., Poad, Berwyck L.J., Nelson, Colleen C., Ellis, Shane R., Heeren, Ron M.A., Sadowski, Martin C., & Blanksby, Stephen J. (2021) Apocryphal FADS2 activity promotes fatty acid diversification in cancer. Cell Reports, 34(6), Article number: 108738.
https://eprints.qut.edu.au/208094/
Research areas
Cancer
cell
biology
Cite this collection
Young, Reuben; Bowman, Andrew; Tousignant, Kaylyn; Poad, Berwyck; Gunter, Jennifer; Philp, Lisa; Nelson, Colleen; Ellis, Shane; Heeren, Ron; Sadowski, Martin; Blanksby, Stephen; (2021): Lipid Isomer Compartmentalisation. Queensland University of Technology. (Dataset) https://doi.org/10.25912/RDF_1638495738287
Partner institution
Maastricht MultiModal Molecular Imaging (M4I)
https://www.maastrichtuniversity.nl/research/m4i-division-imaging-mass-spectrometry
Access the data
Data file types
.wiff and .wiff.scan files for use with AbSciex instruments and software; raw files for use with ThermoFisherScientific instruments and software; .xlsx files for use with MS Excel software; .fig files to be used with MatLab Image files (.png, .tif)
Licence
Creative Commons Attribution-NonCommercial-Share Alike 4.0 (CC-BY-NC-SA)
http://creativecommons.org/licenses/by-nc-sa/4.0/
Copyright
© Reuben S. E. Young, 2021.
Dates of data collection
From 2019-01-01 to 2020-10-30
Connections
Has association with
Has chief investigator
Contacts
Name: Dr Reuben Young
Email: r22.young@qut.edu.au
Other
Date record created:
2021-11-25T11:51:45
Date record modified:
2024-10-02T09:43:45
Record status:
Published - Open Access